Rozzano
Location
15 km south of Milan
Area
About 5.000 m2
Reactors capacity
About 35 m3 (among Stainless Steel and Glass Lined Reactors)
Operating conditions
Ranging from high vacuum
(1 mm Hg to 6 bar pressure and temperature
from - 15ºC to 180ºC)
Finishing
Milling, sieving, blending and packaging are performed in air controlled and segregated areas
Purified water
Produced by a validated ROS plant
Warehousing
Fully air conditioned for APIs, air controlled for intermediates and raw materials
Certification
AIFA, US FDA
Rozzano Profile
The Rozzano site (formerly named ICM – Industria Chimica Milanese SpA), started manufacturing operations in late 1958. Since its beginning the multipurpose plant is worldwide famous for production of Phenothiazine tranquilizers and antihistaminics, 50% of which are exported to the USA. In 1998 the Rozzano site successfully expanded it production to aminoglucoside antibiotics for which a fully dedicated plant was constructed.
The Rozzano site was first inspected by the US FDA in late 1980 and its facilities – fully complying with GMPs – are routinely audited by the Italian Ministry of Health and international clients.
Technologies
The following chemical reactions can be performed at Rozzano:
- Alkyline condensations
- Alkylations
- Aminations
- Catalytic Hydrogenations
- Dehydrogenations
- Esterifications
- Halo-derivative preparations
- High temperature reactions (up to 180ºC)
- Methylations
- Optical isomers separations
- Oxyethylations
- Phosphonations
